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About

 Dr. David Larbi Simpong, a seasoned Clinical Laboratory Scientist and neuroscientist, is a faculty member at the University of Cape Coast (UCC) and a visiting faculty at the Kintampo College of Health and Well-being, both located in Ghana. Driven by his commitment to advancing dementia and Alzheimer's disease (AD) diagnosis, he has forged collaborative partnerships with numerous institutions and individuals both domestically and internationally. 

Currently, Dr. Simpong is spearheading efforts to optimize innovative laboratory diagnostic platforms to enable early and accurate detection of dementia and AD in Ghana. A key component of his research involves establishing a biobank of brain tissue and body fluids (blood, urine, and saliva) from individuals with dementia in Ghana. This invaluable resource will serve as a foundation for further research into the early detection and diagnosis of these conditions. Building on his previous research measuring both free-floating and enwrapped tau protein in the peripheral blood of dementia patients, Dr. Simpong and his postgraduate students are currently working on profiling genes associated with dementia among the African population. 

Leveraging existing collaborations with the Ghana Health Service and teaching hospitals, Dr. Simpong envisions a future where culturally sensitive and comprehensive platforms for measuring blood and cerebrospinal fluid-based tau and beta amyloid biomarkers are readily accessible in Ghana by 2030 

Focus & expertise

Recent activity

🧪
Project Nov 2024

Blood as a potential souce for measuring tau and beta amyloid protein - A simple but reliable platform for early diagnosis of Alzheimer's disease in Ghana

🧪
Project Nov 2024

Profillig genes associated with dementia and Alzheimer's disease in Ghanaian population

🧪
Project Nov 2024

Central Nervous System Diseases and Deaths in Middle-Aged Adults: A 10-year Study in a Ghanaian Tertiary Care Facility

🧪
Project Nov 2024

The Montreal Cognitive Assessment tool could be a useful platform for screening mild cognitive impairment in Ghana among those with at least seven years of formal education: A cross-sectional pilot study in the Cape Coast Metropolis

🧪
Project Oct 2024

Micronutrient for improve cognition

Background

🎓 Education & qualifications

Master of Education in Teaching in Higher Education

University of Cape Coast

2024

Doctor of Philosophy in Neuroscience

University of Leipzig

2020

Master of Philosophy in Pathology

University of Ghana

2013

Bachelor of Science in Medical Laboratory Science

University of Cape Coast

2009

Career & positions

Departmental Registration & Exams Officer

Department of Medical Laboratory Science

Aug, 2022 to Aug, 2023

Faculty/School Registration & Exams Officer

School of Allied Health Sciences

Aug, 2023 to Aug, 2025

Teaching & projects

 1.      Student-Centered Learning: To prioritize active learning techniques, such as group discussions, problem-based learning, and hands-on experiments. 

2.      Real-World Application: Connect neuroscience concepts to real-world examples and applications, such as neurodegenerative diseases, mental health disorders, and technological advancements. 

3.      Lifelong Learning: Promotion of growth mindset, emphasizing the importance of perseverance, resilience, and a willingness to embrace challenges. 

4.      Interdisciplinary Approach: By encouraging students to think critically about the complex interplay between biological, psychological, and social factors that shape human behavior. 

Teaching philosophy

Projects

🧪

Profillig genes associated with dementia and Alzheimer's disease in Ghanaian population

Lead

May 2024 - Present

🧪

The Montreal Cognitive Assessment tool could be a useful platform for screening mild cognitive impairment in Ghana among those with at least seven years of formal education: A cross-sectional pilot study in the Cape Coast Metropolis

Lead

August 2023 - Present

🧪

Micronutrient for improve cognition

Lead

July 2023 - October 2023

🧪

Central Nervous System Diseases and Deaths in Middle-Aged Adults: A 10-year Study in a Ghanaian Tertiary Care Facility

Lead

October 2022 - Present

🧪

Blood as a potential souce for measuring tau and beta amyloid protein - A simple but reliable platform for early diagnosis of Alzheimer's disease in Ghana

Lead

February 2020 - Present

Publications 38 works

ORCID 0000-0002-9194-3762 →

2026

Association between lipid levels and dementia risk among older Ghanaian adults

Foster Appiah, David Larbi Simpong, Esther Marfo, George Nkrumah Osei et al.

Journal of Alzheimer s Disease · Article · 1 citation · Source: OpenAlex

Parasitic Infections and Associated Cognitive Outcome Among School‐Aged Children in Africa: A Systematic Review

A. Osafo Adu, David Larbi Simpong, David Mawutor Donkor, Kwaku Sarfo Manu et al.

Brain and Behavior · Review · 1 citation · Source: OpenAlex

Peripheral oxidative stress related biomarkers in Alzheimer's disease: A systematic review of their implications for diagnosis and disease monitoring

George Nkrumah Osei, Linus Kpelle, Foster Appiah, Kabutey Nartey et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · Review · 1 citation · Source: OpenAlex

Population disparities in Alzheimer's disease: A systematic review of fluid and neuroimaging biomarkers

Linus Kpelle, Ansumana Bockarie, Maxwell Hubert Antwi, George Nkrumah Osei et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · Review · 1 citation · Source: OpenAlex

Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings

Foster Appiah, David Larbi Simpong, George Nkrumah Osei, John Dogah et al.

Journal of Alzheimer s Disease Reports · Article · Source: OpenAlex

2025

Cytokines and immune biomarkers in neurodegeneration and cognitive function: A systematic review among individuals of African ancestry

Maxwell Hubert Antwi, Ansumana Bockarie, George Nkrumah Osei, David Mawutor Donkor et al.

Alzheimer s & Dementia · Review · 12 citations · Source: OpenAlex

Genetic and environmental risk factors for dementia in African adults: A systematic review

David Mawutor Donkor, E.K. Marfo, Ansumana Bockarie, Edward Jenner Tettevi et al.

Alzheimer s & Dementia · Review · 12 citations · Source: OpenAlex

Diagnostic potential of near‐infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource‐limited settings

George Nkrumah Osei, Ansumana Bockarie, Albert Akpalu, Peter Osei‐Wusu Adueming et al.

Alzheimer s & Dementia · Article · 5 citations · Source: OpenAlex

Evaluation of sleep quality and its determinants among individuals with diabetes mellitus and/or hypertension: A cross-sectional study

John Dogah, Ansumana Bockarie, Eric Kwame Kunkah, Adwoa Abrafi Boampong et al.

IBRO Neuroscience Reports · Article · 4 citations · Source: OpenAlex

Antibiotic‐Induced Gut Dysbiosis Modulates Alzheimer's Disease‐Associated Gene Expression and Protein Aggregation in 3xTg‐AD Mice via the Gut–Brain Axis

Edward Jenner Tettevi, David Larbi Simpong, Mahmoud Bukar Maina, Samuel Adjei et al.

Brain and Behavior · Article · 3 citations · Source: OpenAlex

Anemia status is associated with insufficient iodine levels in pregnant women in rural settings: a two-centre observational study

David Larbi Simpong, Charles Ekow Spike Cartey, Olivia Mawunyo Timpo, Joseph Boachie et al.

Discover Medicine · Article · 1 citation · Source: OpenAlex

Anaemia status is associated with insufficient iodine levels in pregnant women in rural settings; a two-centre observational study

David Larbi Simpong, Charles Ekow Spike Cartey, Olivia Mawunyo Timpo, Joseph Boachie et al.

Research Square · Preprint · Source: OpenAlex

Pattern of central nervous system related diseases and deaths: a 10-year study in a Ghanaian tertiary care facility

Ansumana Bockarie, Richael Odarkor Mills, Kofi Ulzen‐Appiah, Albert Akpalu et al.

Brain Disorders · Article · Source: OpenAlex

2024

Poor sleep quality remains a major challenge among tertiary education students in Ghana: A cross-sectional study in a Ghanaian University

David Larbi Simpong, Ansumana Bockarie, Akosua Bema Kumah, Alex Bismark Atta-Owusu et al.

IBRO Neuroscience Reports · Article · 14 citations · Source: OpenAlex + ORCID

Exploration of demographic prevalence of mild cognitive impairment using Montreal cognitive assessment: A cross-sectional pilot study in the Cape Coast Metropolis, Ghana.

David Larbi Simpong, George Nkrumah Osei, R. J. Mills, Christopher Amaleyele Anyebem et al.

IBRO Neuroscience Reports · Article · 5 citations · Source: OpenAlex + ORCID

In Silico Identification of a Potential TNF-Alpha Binder Using a Structural Similarity: A Potential Drug Repurposing Approach to the Management of Alzheimer’s Disease

Edward Jenner Tettevi, Deryl Nii Okantey Kuevi, Balagra Kasim Sumabe, David Larbi Simpong et al.

BioMed Research International · Article · 5 citations · Source: OpenAlex + ORCID

The Montreal Cognitive Assessment Tool Could Be a Useful Platform for Screening Mild Cognitive Impairment in Ghana Among Those with at Least Seven Years of Formal Education: A Cross-Sectional Pilot Study in the Cape Coast Metropolis

David Larbi Simpong, George Nkrumah Osei, Richael Odarkor Mills, Christopher Amaleyele Anyebem et al.

SSRN Electronic Journal · Preprint · Source: OpenAlex

2023

Establishing pregnancy-specific haematological reference intervals in Ghana; a three-center cross-sectional study

Nicodemus Larbi Simpong, Charity Tenu Afefa, Leander Yimpuri, Betty Akum et al.

PLoS ONE · Article · 12 citations · Source: OpenAlex + ORCID

HBV Infection Is an Intermediate‐Risk Disease, Whereas Anaemia Is a Mild‐to‐Moderate Public Health Problem in Young Ghanaian Adults: A Four‐Year Retrospective Analysis of Students’ Medical Records

Samuel Amoah, Andrew Nicholas Yartey, Praise Fosu Adjei, M. Owusu–Akyaw et al.

BioMed Research International · Article · 4 citations · Source: OpenAlex

Tectona grandis (Teak Tree) Young Leaf Extract as a Histological Stain

Cecilia Smith‐Togobo, Adam Abdul Fatau, Magalys Cuba Lopez, Felix Kpor et al.

Journal of Biomedical Science and Engineering · Article · 1 citation · Source: OpenAlex

2022

A Review of African Medicinal Plants and Functional Foods for the Management of Alzheimer's Disease-related Phenotypes, Treatment of HSV-1 Infection and/or Improvement of Gut Microbiota

Edward Jenner Tettevi, Mahmoud Bukar Maina, David Larbi Simpong, Mike Y. Osei‐Atweneboana et al.

Journal of Evidence-Based Integrative Medicine · Article · 14 citations · Source: OpenAlex + ORCID

Anaemia Prevalence More Than Doubles in an Academic Year in a Cohort of Tertiary Students: A Repeated-Measure Study in Cape Coast, Ghana

Regina Elorm Amoaning, Ernestina Siaw Amoako, Grace Arezie Kyiire, Dennis Dela Owusu et al.

Advances in Hematology · Article · 9 citations · Source: OpenAlex

2021

Poor haemoglobin-haematocrit agreement in apparently healthy adult population; a cross-sectional study in Cape Coast Metropolis, Ghana

Grace Ali-Baya, Emmanuel Zenile, Bridgette Obuor Aikins, Regina Elorm Amoaning et al.

Heliyon · Article · 4 citations · Source: OpenAlex

Crude extracts from Allium cepa skin and Sorghum bicolor seed can provide as non-toxic and eco-friendly cytoplasmic stains

Cecilia Krampah, Franklin Nyanzu, Abraham Quaye, Patrick Adu et al.

Practical Laboratory Medicine · Article · 2 citations · Source: OpenAlex + ORCID

2020

Poor iron store recovery in voluntary blood donors in the northern zone of Ghana; a five-month three-centre cohort study

Patrick Adu, Simon Banom, Mawunya Komla Amediku, Regina Elorm Amoaning et al.

Transfusion and Apheresis Science · Article · 3 citations · Source: OpenAlex + ORCID

2019

The Effect of Chemotherapy on Clinical, Haematological and Biochemical Profile in Breast Cancer Patients Undergoing Chemotherapy at Cape Coast Teaching Hospital; A Longitudinal Study

Rebecca Peniel Storph, Frank Naku Ghartey, Richard Kobina Dadzie Ephraim, Enoch Mensah et al.

Journal of Cancer and Tumor International · Article · 2 citations · Source: OpenAlex

2018

TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole

Moritz Oberstadt, Jens Stieler, David Larbi Simpong, Ute Römuß et al.

Scientific Reports · Article · 39 citations · Source: OpenAlex + ORCID

High Iodine Deficiency among Pregnant Women in Periurban Ghana: A Hospital-Based Longitudinal Study

David Larbi Simpong, Yaw Asante Awuku, Kenneth Kwame Kye-Amoah, Martin Tangnaa Morna et al.

Journal of Nutrition and Metabolism · Article · 6 citations · Source: OpenAlex + ORCID

HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana

David Larbi Simpong, Richard Harry Asmah, Cecilia Krampah, Patrick Kafui Akakpo et al.

The Scientific World JOURNAL · Article · 5 citations · Source: OpenAlex + ORCID

2017

Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa

Yaw Asante Awuku, David Larbi Simpong, Ishmael Kunateh Alhassan, Derek Anamaale Tuoyire et al.

BMC Public Health · Article · 95 citations · Source: OpenAlex + ORCID

Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana

Du-Bois Asante, Richard Harry Asmah, Andrew A. Adjei, Foster Kyei et al.

The Scientific World JOURNAL · Article · 19 citations · Source: OpenAlex + ORCID

Addressing the Challenge of Iodine Deficiency in Developing Countries

David Larbi Simpong

MOJ Public Health · Article · 9 citations · Source: OpenAlex + ORCID

2016

Assessment of iodine status among pregnant women in a rural community in ghana - a cross sectional study

David Larbi Simpong, Patrick Adu, Rashid Bashiru, Martin Tangnaa Morna et al.

Archives of Public Health · Article · 38 citations · Source: OpenAlex + ORCID

Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Trait among Prospective Blood Donors: A Cross-Sectional Study in Berekum, Ghana

Patrick Adu, David Larbi Simpong, Godfred Takyi, Richard Kobina Dadzie Ephraim

Advances in Hematology · Article · 21 citations · Source: OpenAlex + ORCID

2015

Application of sigma metrics for the assessment of quality control in clinical chemistry laboratory in Ghana: A pilot study

Justice Afrifa, SethA Gyekye, WilliamKBA Owiredu, RichardKD Ephraim et al.

Nigerian Medical Journal · Article · 26 citations · Source: OpenAlex + ORCID

2014

Co-existence of malaria and urinary tract infection among children under five: A cross-sectional study of the Assin-South Municipality, Ghana

RKD Ephraim, MA Nyame, Samuel Asamoah Sakyi, Enoch O. Antoh et al.

Journal of Medical and Biomedical Sciences · Article · 4 citations · Source: OpenAlex + ORCID

2013

Human Epidermal Growth Factor Receptor -2 Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma - A Retrospective Study on Ghanaian Cancer Patients who attended Korle Bu Teaching Hospital

David Larbi Simpong

Dissertation · Source: OpenAlex

OpenAlex updated 10 Sep 2026

Engagements

📅 Conferences attended

2018 68th Nobel Laureate meeting medicine and physiology Participant · Lindau, Germany
2019 European Alzheimer's Disease Consortium Participant · Leipzig, Germany

Honors & affiliations

🏅
Equipment support
Programme "Shaping development-oriented migration · 2024
🏅
Research grant - GH 59,203
DRIC - University of Cape Coast · 2022
🏅
Travel Grant
DAAD · 2018
🏅
PhD scholarship
DAAD · 2016
Member
Allied Health Profession, Ghana · 2014

Colleagues & frequently viewed together

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