Samuel Acquah assumed duty as Lecturer in January, 2008 at the Department of Medical Biochemistry, School of Medical Sciences, University of Cape Coast. He obtained his B.Sc. Biochemistry degree from the Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, in 2002. He subsequently graduated from Ghent University, Ghent, Belgium with M.Sc. Food Science and Nutrition in 2004 and a second M.Sc. degree in Molecular Biotechnology (Medical Option) in 2005 from the same University. In April, 2014, he obtained his doctorate degree in Zoology (parasitology) from the University of Cape Coast, Ghana, on the topic "Effects of Falciparum malaria on levels of selected biomarkers of cardiovascular disease risk in type 2 diabetics and non-diabetic controls". 

Samuel Acquah was promoted to the rank of Senior Lecturer in April, 2012 and Associate Professor in August,  2017. With more than 17 years  experience of teaching and research at the University of Cape Coast, Prof. Samuel Acquah has taught several courses and modules and supervised a number of undergraduate and postgraduate project works. He has examined a number of theses as an External Examiner and Internal Examiner at the postgraduate level. Above all, he has served in several administrative positions including   Registration Officer, Head of Department and Vice-Dean. He has served and continues to serve on a number of Committees and Boards in the University. Prof. Samuel Acquah is the immediat  past HoD of Department of Medical Biochemistry,  School of Medical Sciences,  College of Health and Allied Sciences,  University of Cape Coast. His current research focuses on the diabetogenic potential of infection  in general with a focus on malaria and coronavirus disease 2019 (COVID-19) with the view to gaining an in-depth understanding of the contribution of Falciparum malaria to the upsurge of type 2 diabetes mellitus in malaria-endemic regions of the globe in the context of post-COVID-19 pandemic. He is also interested in understanding the diabetogenic role of COVID-19 with or without malaria. Specifically,  he focuses on how these infections contribute to the development of insulin resistance, which is a cardinal risk factor for the development of type 2 diabetes mellitus. He also has an interest in the long-term consequence of infectious diseases in general on the health and well-being of the affected and how the interaction between infectious and chronic non-infectious diseases impacts the development of chronic diseases. He is a reviewer to several journals in the area of diabetes research, malaria and infectious diseases and metabolic scienc . He has a number of publications in peer-reviewed journals to his credit.